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(+/-)-BAY-1251152

ORB1089384
Biorbyt
CAS Number1610358-53-6
Product group Chemicals
Molecular Weight404.4336295
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Overview

  • Supplier
    Biorbyt
  • Product Name
    (+/-)-BAY-1251152 [1610358-53-6]
  • Delivery Days Customer
    10
  • CAS Number
    1610358-53-6
  • Certification
    Research Use Only
  • Molecular Formula
    C19H18F2N4O2S
  • Molecular Weight
    404.4336295
  • Scientific Description
    AY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor. BAY1251152 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins. This may cause cell cycle arrest and induce apoptosis, which may lead to a reduction in tumor cell proliferation.
  • SMILES
    S(C)(CC1C=CN=C(C=1)NC1C=C(C(=CN=1)F)C1C=CC(=CC=1OC)F)(=N)=O
  • UNSPSC
    12352200

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