BAY 61-3606 HCl [1615197-10-8]

TargetMol Chemicals

BAY 61-3606 HCl [1615197-10-8]

44

1615197-10-8

Research Use Only

BAY 61-3606 HCl

C20H19ClN6O3

426.86

BAY 61-3606 HCl is a cell-permeable, reversible inhibitor of spleen tyrosine kinase. BAY 61-3606 HCl can inhibit degranulation and block cytokine release from mast cells. Oral administration of BAY 61-3606 to rats was shown to suppress antigen-induced passive cutaneous anaphylactic reaction, bronchoconstriction, and bronchial edema. It can also sensitize MCF-7 breast cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis by inhibiting Cdk9. This compound has been used in a pre-clinical model to explore the feasibility of targeting Syk in the treatment of retinoblastoma.

3 years

Cl.COc1ccc(cc1OC)-c1cc2nccn2c(Nc2ncccc2C(N)=O)n1

-20°C

12352200