Formalin-fixed, paraffin-embedded human Hodgkins lymphoma stained with GTX23193 using peroxidase-conjugate and AEC chromogen. Note cell membrane staining of Reed-Sternberg cells.
Formalin-fixed, paraffin-embedded human Hodgkins lymphoma stained with GTX23193 using peroxidase-conjugate and AEC chromogen. Note cell membrane staining of Reed-Sternberg cells.
Bcl-X antibody [2H12]
GTX23193
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Porcine, Rat
TargetBCL2L1
Overview
- SupplierGeneTex
- Product NameBcl-X antibody [2H12]
- Delivery Days Customer9
- Antibody SpecificityGTX23193 reacts with both Bcl-XS and Bcl-XL proteins.
- ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID2H12
- ConjugateUnconjugated
- Gene ID598
- Target nameBCL2L1
- Target descriptionBCL2 like 1
- Target synonymsapoptosis regulator Bcl-X; BCL2L; bcl-2-like protein 1; BCLX; Bcl-X; BCL-XL/S; PPP1R52; protein phosphatase 1, regulatory subunit 52
- HostMouse
- IsotypeIgG2a
- Protein IDQ07817
- Protein NameBcl-2-like protein 1
- Scientific DescriptionThe protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015]
- ReactivityHuman, Mouse, Porcine, Rat
- Storage Instruction2°C to 8°C
- UNSPSC12352203