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BCL10 antibody [N1C3]

Research Use Only
GTX109159
GeneTex
ApplicationsImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetBCL10
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Overview

  • Supplier
    GeneTex
  • Product Name
    BCL10 antibody [N1C3]
  • Delivery Days Customer
    9
  • Antibody Specificity
    IP/MS validation was supported by references (PMID:30377394)
  • Application Supplier Note
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.45 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID8915
  • Target name
    BCL10
  • Target description
    BCL10 immune signaling adaptor
  • Target synonyms
    B cell CLL/lymphoma 10; B-cell lymphoma/leukemia 10; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; CARD-containing molecule enhancing NF-kappa-B; CARD-containing proapoptotic protein; CARMEN; caspase-recruiting domain-containing protein; cCARMEN; c-E10; CED-3/ICH-1 prodomain homologous E10-like regulator; cellular homolog of vCARMEN; cellular-E10; CIPER; CLAP; hCLAP; IMD37; mammalian CARD-containing adapter molecule E10; mE10
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDO95999
  • Protein Name
    B-cell lymphoma/leukemia 10
  • Scientific Description
    This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • A high-throughput pipeline for validation of antibodies. Sikorski K et al., 2018 Nov, Nat Methods
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