Western blot analysis of extracts from normal (control) and BCL10 knockout (KO) HeLa cells using BCL10 Polyclonal Antibody at dilution of 1:1000.
Western blot analysis of extracts from normal (control) and BCL10 knockout (KO) HeLa cells using BCL10 Polyclonal Antibody at dilution of 1:1000.
BCL10 Polyclonal Antibody
E-AB-60188
Product group Antibodies
Overview
- SupplierElabscience
- Product NameBCL10 Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionThis gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.
- UNSPSC12352203