Bcr (phospho Tyr177) antibody

GeneTex

Bcr (phospho Tyr177) antibody

9

WB: 1:500-1:1000. IHC-P: 1:50-1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

BCR

BCR activator of RhoGEF and GTPase

ALL, BCR1, CML, D22S11, D22S662, PHL, breakpoint cluster region protein, BCR, RhoGEF and GTPase activating protein, BCR/FGFR1 chimera protein, BCR::ABL1 fusion protein, FGFR1/BCR chimera protein, breakpoint cluster region, renal carcinoma antigen NY-REN-26

Rabbit

IgG

Breakpoint cluster region protein

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Human

-20°C or -80°C,2°C to 8°C

41116161