Berberine chloride [633-65-8]

Chemodex

Berberine chloride [633-65-8]

10

633-65-8

Research Use Only

>98%

C20H17NO4 . HCl

335.3 . 36.5

Chemical. CAS: 633-65-8. Formula: C20H17NO4 . HCl. MW: 335.3 . 36.5. Synthetic Natural fluorescent dye, used in histology for staining heparin in mast cells. An isoquinoline alkaloid, which shows antibacterial, antifungal, anti-inflammatory, anti-oxidant, antidiabetic, antiviral and anticancer activity. It inhibits cell growth and induces apoptosis in a variety of cancer cell lines. Broad spectrum enzyme inhibitor, affects N-acetyltransferase, cyclooxygenase-2, and topoisomerase activities and gene/protein expression. Increases adiponectin expression, upregulates LDLR and insulin receptor. Anti-hyperglycemic, by inhibition of aldose reductase, inducing glycolysis, preventing insulin resistance through increasing insulin receptor expression and acting like incretins. Activates AMPK and ERK. Potent, uncompetitive, reversible IDO 1 inhibitor with IC50 values of 7 microM (cell-based assay) and 9.3 microM (enzymatic assay), and Ki value 8microM. - Natural fluorescent dye, used in histology for staining heparin in mast cells. An isoquinoline alkaloid, which shows antibacterial, antifungal, anti-inflammatory, anti-oxidant, antidiabetic, antiviral and anticancer activity. It inhibits cell growth and induces apoptosis in a variety of cancer cell lines. Broad spectrum enzyme inhibitor, affects N-acetyltransferase, cyclooxygenase-2, and topoisomerase activities and gene/protein expression. Increases adiponectin expression, upregulates LDLR and insulin receptor. Anti-hyperglycemic, by inhibition of aldose reductase, inducing glycolysis, preventing insulin resistance through increasing insulin receptor expression and acting like incretins. Activates AMPK and ERK. Potent, uncompetitive, reversible IDO1 inhibitor with IC50 values of 7 microM (cell-based assay) and 9.3 microM (enzymatic assay), and Ki value 8microM. Inhibits BAFF production in H. pylori-induced chronic gastritis.

[Cl-].COC1=C(OC)C2=C[N+]3=C(C=C2C=C1)C1=CC2=C(OCO2)C=C1CC3

2°C to 8°C

41116134