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Berberine chloride

S2271
Selleck Chemicals
CAS Number633-65-8
Product group Chemicals
Estimated Purity...
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Overview

  • Supplier
    Selleck Chemicals
  • Product Name
    Berberine chloride (NSC 646666) [633-65-8]
  • Delivery Days Customer
    9
  • CAS Number
    633-65-8
  • Certification
    Research Use Only
  • Estimated Purity
    ...
  • Scientific Description
    Berberine chloride is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.
  • Storage Instruction
    -80°C
  • UNSPSC
    51202000