Berberine chloride (NSC 646666) [633-65-8]
S2271
CAS Number633-65-8
Product group Chemicals
Overview
- SupplierSelleck Chemicals
- Product NameBerberine chloride (NSC 646666) [633-65-8]
- Delivery Days Customer9
- CAS Number633-65-8
- CertificationResearch Use Only
- Scientific DescriptionBerberine chloride (NSC 646666, Natural Yellow 18) is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.
- UNSPSC12352200