beta Amyloid (1-42) antibody - Conformation Specific
GTX134510
ApplicationsDot Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Neutralisation/Blocking
Product group Antibodies
ReactivityHuman, Mouse
TargetAPP
Overview
- SupplierGeneTex
- Product Namebeta Amyloid (1-42) antibody - Conformation Specific
- Delivery Days Customer9
- Application Supplier NoteIHC-P: 1:100-1:1000. ELISA: 1:1000-1:10000. Sandwich ELISA: . *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsDot Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Neutralisation/Blocking
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.45 mg/ml
- ConjugateUnconjugated
- Gene ID351
- Target nameAPP
- Target descriptionamyloid beta precursor protein
- Target synonymsAAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, alpha-sAPP, preA4, amyloid-beta precursor protein, alzheimer disease amyloid A4 protein homolog, alzheimer disease amyloid protein, amyloid beta (A4) precursor protein, amyloid beta A4 protein, amyloid precursor protein, beta-amyloid peptide, beta-amyloid peptide(1-40), beta-amyloid peptide(1-42), beta-amyloid precursor protein, cerebral vascular amyloid peptide, peptidase nexin-II, protease nexin-II, testicular tissue protein Li 2
- HostRabbit
- IsotypeIgG
- Protein IDP05067
- Protein NameAmyloid-beta precursor protein
- Scientific DescriptionThis gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Yang Y, Yu Q, Li B, et al. A single dose of lipopolysaccharide elicits autofluorescence in the mouse brain. Front Aging Neurosci. 2023,15:1126273. doi: 10.3389/fnagi.2023.1126273Read this paper
- Amano A, Sanjo N, Araki W, et al. Peripheral administration of nanomicelle-encapsulated anti-Aβ oligomer fragment antibody reduces various toxic Aβ species in the brain. J Nanobiotechnology. 2023,21(1):36. doi: 10.1186/s12951-023-01772-yRead this paper
- Wang H, Lv JJ, Zhao Y, et al. Endothelial genetic deletion of CD147 induces changes in the dual function of the blood-brain barrier and is implicated in Alzheimer's disease. CNS Neurosci Ther. 2021,27(9):1048-1063. doi: 10.1111/cns.13659Read this paper
- Dinkel F, Trujillo-Rodriguez D, Villegas A, et al. Decreased Deposition of Beta-Amyloid 1-38 and Increased Deposition of Beta-Amyloid 1-42 in Brain Tissue of Presenilin-1 E280A Familial Alzheimer's Disease Patients. Front Aging Neurosci. 2020,12:220. doi: 10.3389/fnagi.2020.00220Read this paper




