beta Amyloid antibody

GeneTex

beta Amyloid antibody

9

WB: 1:1000-1:5000. ICC/IF: 1:50-1:200. IHC-P: 1:50-1:200. IHC-Fr: 1:50-1:200. ELISA: 1:10000-1:30000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1.1 mg/ml

Unconjugated

APP

amyloid beta precursor protein

AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, alpha-sAPP, preA4, amyloid-beta precursor protein, alzheimer disease amyloid A4 protein homolog, alzheimer disease amyloid protein, amyloid beta (A4) precursor protein, amyloid beta A4 protein, amyloid precursor protein, beta-amyloid peptide, beta-amyloid peptide(1-40), beta-amyloid peptide(1-42), beta-amyloid precursor protein, cerebral vascular amyloid peptide, peptidase nexin-II, protease nexin-II, testicular tissue protein Li 2

Rabbit

IgG

Amyloid-beta precursor protein

Beta Amyloid, often abbreviated as A-beta, is a protein that builds up in the brains of persons with Alzheimers disease, collecting in clumps called plaques or senile plaques. While some researchers question whether Beta Amyloid is the cause of the dementia, most agree that it is involved in the disruption of thinking that is a hallmark of the disease. In some cases of familial Alzheimers disease, mutations in genes for the proteins called the presenilins lead to increased production of myloid. Researchers have been looking at how presenilin-1 in particular contributes to the excess buildup of Beta Amyloid. Presenilin-1 apparently acts to increase the activity of gamma-secretase, an enzyme that changes a normal protein (amyloid precursor protein or APP) into Beta Amyloid itself. Furthermore, presenilin-1 might be gamma-secretase.

Human, Mouse

-20°C or -80°C,2°C to 8°C

12352203