beta-Rubromycin [27267-70-5]

TargetMol Chemicals

beta-Rubromycin [27267-70-5]

16

27267-70-5

Chemical

Research Use Only

bèta-Rubromycin

C27H20O12

536.445

beta-Rubromycin is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities.1 It inhibits the growth of HMO2, KATO-III, and MCF-7 cells with GI50 values of 0.5, 0.84, and <0.1 microM, respectively. beta-rubromycin inhibits HIV-1 reverse transcriptase activity by 39.7% when used at a concentration of 10 microM. It also has antibacterial activity against Gram-positive bacteria. The structure of beta-rubromycin was originally described as containing an ortho-quinone group, but it was revised to a para-quinone group in 2000 using organic and biosynthetic methods, as well as spectroscopic analysis.1,2,3

3 years

COC(=O)c1cc2cc3CC[C@]4(CC5=C(O4)C(=O)c4c(O)c(OC)cc(OC)c4C5=O)Oc3c(O)c2c(=O)o1 - c:13 -

-20°C

12352200