BI-4020

MedChem Express

BI-4020 [2664214-60-0]

10

2664214-60-0

Research Use Only

99.28

C30H38N8O2

542.68

BI-4020 is a fourth-generation, orally active, and non-covalent EGFR tyrosine kinase inhibitor. BI-4020 inhibits not only the triple mutant EGFR del19 T790M C797S variant ( IC 50 =0.2 nM in BaF3 cell lines) but also the double mutant EGFR del19 T790M and primary mutant EGFR del19 ( IC 50 =1 nM). BI-4020 also shows activity against EGFR wt ( IC 50 =190 nM). BI-4020 shows high kinome selectivity and good DMPK properties [1] .

O=C(C1=CC(C)=NC(C2=C(OCCC[C@@H](C)C3)N(C)N=C2)=C1)/N=C(N4)/N3C5=C4C=CC(CN6CCN(C)CC6)=C5

-20°C,2°C to 8°C

12352200