BI-4020
M40639
CAS Number2664214-60-0
Product group Chemicals
Molecular Weight542.68
Overview
- SupplierAbMole BioScience
- Product NameBI-4020
- Delivery Days Customer9
- CAS Number2664214-60-0
- Category SupplierChemical
- CertificationResearch Use Only
- Molecular FormulaC30H38N8O2
- Molecular Weight542.68
- Scientific DescriptionBI-4020 is a fourth-generation, orally active, non-covalent EGFR tyrosine kinase macrocyclic inhibitors (TKIs). It inhibits the triple mutant EGFR del19 T790M C797S mutant (IC50=0.2 nM in the BaF3 cell line), the double mutant EGFR del19 T790M, and the single mutant EGFR del19 (IC50=1 nM). and also retains activity against EGFR wt (IC50=190 nM), which can be used in studies related to non-small cell lung cancer (NSCLC).
- SMILESCC1CCCOC2=C(C=N[N]2C)C3=NC(=CC(=C3)C(=O)N=C4NC5=C(C=C(CN6CCN(C)CC6)C=C5)N4C1)C
- UNSPSC12352200