Bio-Connect

BI-4020

M40639
AbMole BioScience
CAS Number2664214-60-0
Product group Chemicals
Molecular Weight542.68
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Overview

  • Supplier
    AbMole BioScience
  • Product Name
    BI-4020
  • Delivery Days Customer
    9
  • CAS Number
    2664214-60-0
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Molecular Formula
    C30H38N8O2
  • Molecular Weight
    542.68
  • Scientific Description
    BI-4020 is a fourth-generation, orally active, non-covalent EGFR tyrosine kinase macrocyclic inhibitors (TKIs). It inhibits the triple mutant EGFR del19 T790M C797S mutant (IC50=0.2 nM in the BaF3 cell line), the double mutant EGFR del19 T790M, and the single mutant EGFR del19 (IC50=1 nM). and also retains activity against EGFR wt (IC50=190 nM), which can be used in studies related to non-small cell lung cancer (NSCLC).
  • SMILES
    CC1CCCOC2=C(C=N[N]2C)C3=NC(=CC(=C3)C(=O)N=C4NC5=C(C=C(CN6CCN(C)CC6)C=C5)N4C1)C
  • UNSPSC
    12352200