Binucleine 2 [220088-42-6]

MedChem Express

Binucleine 2 [220088-42-6]

5

220088-42-6

Research Use Only

C13H11ClFN5

291.71

Binucleine 2 is an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki=0.36 microM), a kinase involved in cell division. It is specific for Drosophila Aurora B kinase, inhibiting it in a dose-dependent manner, with minimal inhibition of human or X. laevis Aurora B kinases at concentrations up to 100 microM. Binucleine 2 induces mitotic and cytokinesis defects in Drosophila Kc167 cells. It prevents Drosophila S2 cells from assembling a contractile ring during cell division when used at a concentration of 40 microM but does not affect ring ingression, suggesting that Aurora B kinase activity is not required for that step.

CN(/C=N/C1=C(C=NN1C2=CC=C(C(Cl)=C2)F)C#N)C

12352200