Binucleine 2 [220088-42-6]

TargetMol Chemicals

Binucleine 2 [220088-42-6]

44

220088-42-6

Research Use Only

Binucleine 2

C13H11ClFN5

291.71

Binucleine 2 is an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki = 0.36 microM), specifically inhibiting it in a dose-dependent manner while exhibiting minimal inhibition of human or X. laevis Aurora B kinases at concentrations up to 100 microM. At 40 microM, Binucleine 2 induces mitotic and cytokinesis defects in Drosophila Kc167 cells and prevents the assembly of a contractile ring during cell division in Drosophila S2 cells, but it does not affect ring ingression, indicating that Aurora B kinase activity is not required for that process.

3 years

N(=CN(C)C)C=1N(N=CC1C#N)C2=CC(Cl)=C(F)C=C2

-20°C

12352200