Bisindolylmaleimide VIII (acetate)

MedChem Express

Bisindolylmaleimide VIII (acetate) [138516-31-1]

10

138516-31-1

Research Use Only

99.68

C26H26N4O4

458.51

Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective protein kinase C (PKC) inhibitor with an IC 50 of 158 nM for rat brain PKC. Bisindolylmaleimide VIII acetate has IC 50 s of 53, 195, 163, 213, and 175 nM for PKC-alpha, PKC-beta I , PKC-beta II , PKC-gamma, PKC-epsilon, respectively [1] . Bisindolylmaleimide VIII acetate facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases [2] .

O=C(C(C1=CN(CCCN)C2=C1C=CC=C2)=C3C4=CN(C)C5=C4C=CC=C5)NC3=O.CC(O)=O

-20°C

12352200