BML-278

MedChem Express

BML-278 [120533-76-8]

14

120533-76-8

Research Use Only

98.49

C24H25NO4

391.46

BML-278 is a SIRT1 activator ( EC 150 : 1 microM). BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in both the paternal and maternal pronucleus. BML-278 improves early embryonic development. BML-278 arrests the cell cycle at the G1/S phase, and reduces senescence in primary human mesenchymal cells. BML-278 reduces tubulin acetylation in U937 cells. BML-278 also increases mitochondrial density in murine C2C12 myoblasts [1] [2] .

CCOC(C1=CN(C=C(C(OCC)=O)C1C2=CC=CC=C2)CC3=CC=CC=C3)=O

-20°C,2°C to 8°C

12352200