BML-278

Biorbyt

BML-278 [120533-76-8]

10

120533-76-8

Research Use Only

100.00%

C24H25NO4

391.46

BML-278 is a SIRT1 activator with an EC150 of 1 microM. It increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, improving early embryonic development. BML-278 induces cell cycle arrest at the G1/S phase in primary human mesenchymal stromal cells, delaying senescence. It also reduces microtubule protein acetylation in U937 cells and increases mitochondrial density in mouse C2C12 myoblasts.

CCOC(=O)C1=CN(Cc2ccccc2)C=C(C1c1ccccc1)C(=O)OCC

-20°C

12352200