BMS-1166 (hydrochloride) [2113650-05-6]

MedChem Express

BMS-1166 (hydrochloride) [2113650-05-6]

10

2113650-05-6

Research Use Only

99.95

C36H34Cl2N2O7

677.57

BMS-1166 hydrochloride is a potent PD-1/PD-L1 immune checkpoint inhibitor. BMS-1166 hydrochloride induces dimerization of PD-L1 and blocks its interaction with PD-1, with an IC50 of 1.4 nM. BMS-1166 hydrochloride antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation[1][2].

O=C(O)[C@@H]1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C(OCCO5)C5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)C[C@H](O)C1.Cl

-20°C,2°C to 8°C

12352200