BMS-986251 [2460133-35-9]

MedChem Express

BMS-986251 [2460133-35-9]

10

2460133-35-9

Research Use Only

C30H29F8NO5S

667.61

BMS-986251 is an orally active and selective RORgammat inverse agonist with an EC50 of 12 nM for RORgammat GAL4. BMS-986251 inhibits IL-17 with an EC50 of 24 nM in human whole blood assay. BMS-986251 demonstrates robust efficacy in mouse acanthosis and Imiquimod-induced (HY-B0180) models (preclinical models of psoriasis)[1].

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