BQ-123 . sodium salt [136553-81-6]

AdipoGen Life Sciences

BQ-123 . sodium salt

10

136553-81-6

Research Use Only

>98%

C31H42N6O7 . Na

609.7 . 23.0

Chemical. CAS: 136655-57-7. Formula: C31H42N6O7 . Na. MW: 609.7 . 23.0. Synthetic. Potent and selective endothelin receptor A (ETA) antagonist. Suppresses the ET-1-induced decrease of LPL activity. Shows protective effects in ischemic acute renal failure. Neuroprotective. Anti-hypertensive. Inhibits ET-1 receptor binding and blocks Ca2+ mobilization, cellular contraction and MAP kinase activation. Cardiovascular agent. Reduces myocardial infarct size and oxidant injury. Selected Reviews. - Potent and selective endothelin receptor A (ETA) antagonist [1-3]. Suppresses the ET-1-induced decrease of LPL activity [4]. Shows protective effects in ischemic acute renal failure [5]. Neuroprotective [6, 10]. Anti-hypertensive [7]. Inhibits ET-1 receptor binding and blocks Ca2+ mobilization, cellular contraction and MAP kinase activation [8]. Cardiovascular agent [9]. Reduces myocardial infarct size and oxidant injury [11]. Selected Reviews [12, 13].

[Na+].CC(C)CC1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC([O-])=O)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC1=O)C(C)C

-20°C,2°C to 8°C

12352200