Immunohistochemistry of paraffin-embedded Human liver cancer tissue using BRCA1 Polyclonal Antibody at dilution 1:35
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using BRCA1 Polyclonal Antibody at dilution 1:35
BRCA1 Polyclonal Antibody
E-AB-10188
Product group Antibodies
Overview
- SupplierElabscience
- Product NameBRCA1 Polyclonal Antibody
- Delivery Days Customer12
- Applications SupplierELISA IHC
- CertificationResearch Use Only
- Concentration0.3mg/ml
- Scientific DescriptionThis gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
- UNSPSC12352203