Confocal microscopy of HepG2 (LPS-treated for 4h) stained with BRCA1-pS1524 Rabbit Polyclonal Antibody AE00298 at 5ug/ml (1h at 37℃). Detection by AF594 (red) for the rabbit BRCA1-pS1524 antibody, AF488 (green) for the mouse beta-tubulin antibody and DAPI (blue) for nuclear staining.
Confocal microscopy of HepG2 (LPS-treated for 4h) stained with BRCA1-pS1524 Rabbit Polyclonal Antibody AE00298 at 5ug/ml (1h at 37℃). Detection by AF594 (red) for the rabbit BRCA1-pS1524 antibody, AF488 (green) for the mouse beta-tubulin antibody and DAPI (blue) for nuclear staining.
BRCA1-pS1524 Polyclonal Antibody AE00298
AE00298
ApplicationsWestern Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetBRCA1
Overview
- SupplierAeonian Biotech
- Product NameBRCA1-pS1524 Polyclonal Antibody
- Delivery Days Customer9
- ApplicationsWestern Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
- Applications SupplierICC, IHC, WB
- Category SupplierAntibody
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID672
- Target nameBRCA1
- Target descriptionBRCA1 DNA repair associated
- Target synonymsBRCA1/BRCA2-containing complex, subunit 1; BRCAI; BRCC1; breast and ovarian cancer susceptibility protein 1; breast cancer 1, early onset; breast cancer type 1 susceptibility protein; BROVCA1; early onset breast cancer 1; Fanconi anemia, complementation group S; FANCS; IRIS; PNCA4; PPP1R53; protein phosphatase 1, regulatory subunit 53; PSCP; RING finger protein 53; RNF53
- HostRabbit
- IsotypeIgG
- Modification TypePhosphorylated
- Protein IDP38398
- Protein NameBreast cancer type 1 susceptibility protein
- Scientific DescriptionBRCA1-pS1524 Polyclonal Antibody AE00298
- Shelf life instructionIntegrity warranted for 24 months after purchase when handled and stored according to instructions, see below.
- ReactivityHuman
- Reactivity SupplierHuman
- Storage Instruction2-8°C
- UNSPSC12352203
References
- García-González L, Paumier JM, Louis L, Pilat D, Bernard A, Stephan D, Jullien N, Checler F, Nivet E, Khrestchatisky M, Baranger K, Rivera S. MT5-MMP controls APP and bèta-CTF/C99 metabolism through proteolytic-dependent and -independent mechanisms relevant for Alzheimer’s disease. FASEB J. 2021 Jul;35(7):e21727. doi: 10.1096/fj.202100593R. PMID: 34117802.Read more
- Long Z, Chen J, Zhao Y, Zhou W, Yao Q, Wang Y, He G. Dynamic changes of autophagic flux induced by Abeta in the brain of postmortem Alzheimer’s disease patients, animal models and cell models. Aging (Albany NY). 2020 Jun 13;12(11):10912-10930. doi: 10.18632/aging.103305. PMID: 32535554.Read more
- Braggin JE, Bucks SA, Course MM, Smith CL, Sopher B, Osnis L, Shuey KD, Domoto-Reilly K, Caso C, Kinoshita C, Scherpelz KP, Cross C, Grabowski T, Nik SHM, Newman M, Garden GA, Leverenz JB, Tsuang D, Latimer C, Gonzalez-Cuyar LF, Keene CD, Morrison RS, Rhoads K, Wijsman EM, Dorschner MO, Lardelli M, Young JE, Valdmanis PN, Bird TD, Jayadev S. Alternative splicing in a presenilin 2 variant associated with Alzheimer disease. Ann Clin Transl Neurol. 2019 Mar 10;6(4):762-777. doi: 10.1002/acn3.755. PMID: 31020001.Read more
- Agholme L, Clarin M, Gkanatsiou E, Kettunen P, Chebli J, Brinkmalm G, Blennow K, Bergström P, Portelius E, Zetterberg H. Low-dose gamma-secretase inhibition increases secretion of Abèta peptides and intracellular oligomeric Abèta. Mol Cell Neurosci. 2017 Dec;85:211-219. doi: 10.1016/j.mcn.2017.10.009. PMID: 29104140.Read more
- Wagner LK, Gilling KE, Schormann E, Kloetzel PM, Heppner FL, Krüger E, Prokop S. Immunoproteasome deficiency alters microglial cytokine response and improves cognitive deficits in Alzheimer’s disease-like APPPS1 mice. Acta Neuropathol Commun. 2017 Jun 24;5(1):52. doi: 10.1186/s40478-017-0453-5. PMID: 28646899.Read more