
Western blot All lanes: BRCC3 antibody at 3ug/ml Lane 1: 293T whole cell lysate Lane 2: MCF-7 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 37, 34, 24, 29 kDa Observed band size: 37 kDa
BRCC3 Antibody
CSB-PA002798ESR2HU
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetBRCC3
Overview
- SupplierCusabio
- Product NameBRCC3 Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID79184
- Target nameBRCC3
- Target descriptionBRCA1/BRCA2-containing complex subunit 3
- Target synonymsBRCA1/BRCA2-containing complex subunit 36; BRCA1-A complex subunit BRCC36; BRCC36; BRISC complex subunit BRCC36; C6.1A; CXorf53; lys-63-specific deubiquitinase BRCC36
- HostRabbit
- IsotypeIgG
- Protein IDP46736
- Protein NameLys-63-specific deubiquitinase BRCC36
- Scientific DescriptionMetalloprotease that specifically cleaves Lys-63-linked polyubiquitin chains. Does not have activity toward Lys-48-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes Lys-63-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes Lys-63-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves Lys-63-linked ubiquitin in various substrates. Mediates the specific Lys-63-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC41116161