BRD4770

AbMole BioScience

BRD4770

9

1374601-40-7

Chemical

Research Use Only

C25H23N3O3

413.47

BRD4770 is a histone methyltransferase G9a inhibitor. BRD4770 inhibited the dimethylation and trimethylation of H3K9, EC50 was 5 uM, and had little effect on H3K27me3, H3K36me3, H3K4me3, and H3K79me3. BRD4770 activates the ataxic telangiectasia mutation (ATM) pathway and induces cell senescence.

COC(=O)C1=CC=C2[N](CCCC3=CC=CC=C3)C(=NC2=C1)NC(=O)C4=CC=CC=C4

12352200