BVES Antibody

Cusabio

BVES Antibody

20

ImmunoFluorescence, ELISA

Research Use Only

Polyclonal

Unconjugated

BVES

blood vessel epicardial substance

blood vessel epicardial substance; CARICK; HBVES; LGMD2X; LGMDR25; POP1; POPDC1; popeye domain-containing protein 1

Rabbit

IgG

Blood vessel epicardial substance

Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells (PubMed:16188940). Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (By similarity). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density (PubMed:26642364). Is also a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury.

Human

-20°C or -80°C

41116161