BX795

MedChem Express

BX795 [702675-74-9]

10

702675-74-9

Research Use Only

99.84

C23H26IN7O2S

591.47

BX795 is a potent and selective inhibitor of PDK1, with an IC50 of 6 nM. BX795 is also a potent and relatively specific inhibitor of TBK1 and IKKepsilon, with an IC50 of 6 and 41 nM, respectively. BX795 blocks phosphorylation of S6K1, Akt, PKCdelta, and GSK3beta, and has lower selectivity over PKA, PKC, c-Kit, GSK3beta etc. BX795 modulates autophagy[1][2][3][4].

O=C(NCCCNC1=C(C=NC(NC2=CC=CC(NC(N3CCCC3)=O)=C2)=N1)I)C4=CC=CS4

-20°C,2°C to 8°C

12352200