C-021 (dihydrochloride)

MedChem Express

C-021 (dihydrochloride) [1784252-84-1]

10

1784252-84-1

Research Use Only

99.92

C27H43Cl2N5O2

540.57

C-021 dihydrochloride is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 dihydrochloride potently inhibits functional chemotaxis in human and mouse with IC 50 s of 140 nM and 39 nM, respectively. C-021 dihydrochloride effectively prevents human CCL22-derived [ 35 S]GTPgammaS from binding to the receptor with an IC 50 of 18 nM [1] .

COC1=CC2=NC(N3CCC(N4CCCCC4)CC3)=NC(NC5CCCCCC5)=C2C=C1OC.[H]Cl.[H]Cl

2°C to 8°C

12352200