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ProductsBack/c-Myc antibody [9E10]

c-Myc antibody [9E10]

GTX75953
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry
DownloadDatasheet
Product group Antibodies
ReactivityHuman
TargetMYC
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Overview

  • Supplier
    GeneTex
  • Product Name
    c-Myc antibody [9E10]
  • Delivery Days Customer
    9
  • Antibody Specificity
    This antibody recognizes the sequence EQKLISEEDL
  • Applications
    Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Conjugate
    Unconjugated
  • Gene ID4609
  • Target name
    MYC
  • Target description
    MYC proto-oncogene, bHLH transcription factor
  • Target synonyms
    avian myelocytomatosis viral oncogene homolog; bHLHe39; class E basic helix-loop-helix protein 39; c-Myc; MRTL; myc proto-oncogene protein; MYCC; myc-related translation/localization regulatory factor; proto-oncogene c-Myc; transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP01106
  • Protein Name
    Myc proto-oncogene protein
  • Scientific Description
    This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • Cauliflower mosaic virus P6 Dysfunctions Histone Deacetylase HD2C to Promote Virus Infection. Li S et al., 2021 Sep 1, Cells
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  • VCP maintains nuclear size by regulating the DNA damage-associated MDC1-p53-autophagy axis in Drosophila. Chang YC et al., 2021 Jul 12, Nat Commun
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  • CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy. Fu SJ et al., 2020 May 26, Cells
    Read more
  • A nonsense mutant of the hepatitis B virus large S protein antagonizes multiple tumor suppressor pathways through c-Jun activation domain-binding protein1. Chiu SY et al., 2019, PLoS One
    Read more
  • NBS1 promotes the endonuclease activity of the MRE11-RAD50 complex by sensing CtIP phosphorylation. Anand R et al., 2019 Apr 1, EMBO J
    Read more
  • Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi. Emperador-Melero J et al., 2018 Aug 24, Nat Commun
    Read more
  • Cdc48/VCP Promotes Chromosome Morphogenesis by Releasing Condensin from Self-Entrapment in Chromatin. Thattikota Y et al., 2018 Feb 15, Mol Cell
    Read more
  • Trichosanthin increases Granzyme B penetration into tumor cells by upregulation of CI-MPR on the cell surface. Li C et al., 2017 Apr 18, Oncotarget
    Read more
  • SEPT12 phosphorylation results in loss of the septin ring/sperm annulus, defective sperm motility and poor male fertility. Shen YR et al., 2017 Mar, PLoS Genet
    Read more
  • Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicity. Ding X et al., 2017 Feb, Neurobiol Dis
    Read more