ProductsBack/c-Myc antibody [9E10]

c-Myc antibody [9E10]

Name: c-Myc antibody [9E10]
SKU: GTX75953_G10
Availability: BackOrder

GTX75953

ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry

DownloadDatasheet

Product group Antibodies

TargetMYC

Overview

Supplier
GeneTex
Product Name
c-Myc antibody [9E10]
Delivery Days Customer
9
Applications
Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry
Certification
Research Use Only
Clonality
Monoclonal
Conjugate
Unconjugated
Gene ID4609
Target name
MYC
Target description
MYC proto-oncogene, bHLH transcription factor
Target synonyms
avian myelocytomatosis viral oncogene homolog; bHLHe39; class E basic helix-loop-helix protein 39; c-Myc; MRTL; myc proto-oncogene protein; MYCC; myc-related translation/localization regulatory factor; proto-oncogene c-Myc; transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog
Host
Mouse
Isotype
IgG1
Protein IDP01106
Protein Name
Myc proto-oncogene protein
Scientific Description
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]
Storage Instruction
2°C to 8°C
UNSPSC
12352203

References

Cauliflower mosaic virus P6 Dysfunctions Histone Deacetylase HD2C to Promote Virus Infection. Li S et al., 2021 Sep 1, Cells
Read more
VCP maintains nuclear size by regulating the DNA damage-associated MDC1-p53-autophagy axis in Drosophila. Chang YC et al., 2021 Jul 12, Nat Commun
Read more
CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy. Fu SJ et al., 2020 May 26, Cells
Read more
A nonsense mutant of the hepatitis B virus large S protein antagonizes multiple tumor suppressor pathways through c-Jun activation domain-binding protein1. Chiu SY et al., 2019, PLoS One
Read more
NBS1 promotes the endonuclease activity of the MRE11-RAD50 complex by sensing CtIP phosphorylation. Anand R et al., 2019 Apr 1, EMBO J
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Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi. Emperador-Melero J et al., 2018 Aug 24, Nat Commun
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Cdc48/VCP Promotes Chromosome Morphogenesis by Releasing Condensin from Self-Entrapment in Chromatin. Thattikota Y et al., 2018 Feb 15, Mol Cell
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Trichosanthin increases Granzyme B penetration into tumor cells by upregulation of CI-MPR on the cell surface. Li C et al., 2017 Apr 18, Oncotarget
Read more
SEPT12 phosphorylation results in loss of the septin ring/sperm annulus, defective sperm motility and poor male fertility. Shen YR et al., 2017 Mar, PLoS Genet
Read more
Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicity. Ding X et al., 2017 Feb, Neurobiol Dis
Read more

c-Myc antibody [9E10]

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Overview

References

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