C188 [823828-18-8]

MedChem Express

C188 [823828-18-8]

10

823828-18-8

Research Use Only

98.29

C19H15NO7S2

433.45

C188 (CPD188) is a STAT3 inhibitor with anticancer effects. C188 inhibits STAT3 SH2/pY-peptide binding (IC50 of 20 microM against pY-peptide binding) and IL-6-mediated STAT3 phosphorylation. C188 is selective for STAT3 over STAT1. C188 inhibits nuclear-to-cytoplasmic translocation of Stat3. C188 shows highly active induces apoptosis in breast cancer cell lines with constitutive Stat3 activation (EC50s of 0.73 microM, 3.96 microM, and 7.01 microM in MDA-MB-468, MDA-MB-231, and MDA-MB-435 cultures, respectively)[1].

O=C(O)C1=CC=C(S(=O)(NC2=C3C=CC=CC3=C(O)C(SCC(O)=O)=C2)=O)C=C1

-20°C,2°C to 8°C

12352200