C3IP1 antibody

GeneTex

C3IP1 antibody

9

WB: 1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot

Research Use Only

Polyclonal

Unconjugated

KLHL12

kelch like family member 12

C3IP1; CUL3-interacting protein 1; DKIR; DKIR homolog; kelch-like protein 12; kelch-like protein C3IP1

Chicken

IgY

Kelch-like protein 12

C3IP1 contains both a BTB/POZ domain (23-130) and a Kelch domain (427-473). The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger(pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation. The structure of the dimerised PLZF BTB/POZdomain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including NCoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk.

Human

-20°C or -80°C,2°C to 8°C

12352203