CALM antibody

GeneTex

CALM antibody

9

WB: 1 microg/mL. IHC-P: 20 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

PICALM

phosphatidylinositol binding clathrin assembly protein

CALM; clathrin assembly lymphoid myeloid leukemia protein; CLTH; LAP; phosphatidylinositol-binding clathrin assembly protein

Rabbit

IgG

Phosphatidylinositol-binding clathrin assembly protein

PICALM, also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area, and is thought to be an important component of the coated pit internalization machinery. Fusion proteins involving PICALM have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia. PICALM is also expressed in neurons and is present at the synapse where it facilitates the endocytosis of the synaptic vesicle protein VAMP2. Recent studies have identified variants of PICALM associated with Alzheimers disease and have suggested this protein may play a role in the endocytosis and recycling of the amyloid protein precursor (APP).

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203