ProductsBack/Calpain 5 antibody [N1C1]

Calpain 5 antibody [N1C1]

Name: Calpain 5 antibody [N1C1]
SKU: GTX103264_G10
Availability: BackOrder

GTX103264

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Product group Antibodies

ReactivityHuman, Mouse, Rat

TargetCAPN5

Overview

Supplier
GeneTex
Product Name
Calpain 5 antibody [N1C1]
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1.39 mg/ml
Conjugate
Unconjugated
Gene ID726
Target name
CAPN5
Target description
calpain 5
Target synonyms
ADNIV, HTRA3, VRNI, nCL-3, calpain-5, calpain htra-3, new calpain 3, testis tissue sperm-binding protein Li 91mP
Host
Rabbit
Isotype
IgG
Protein IDO15484
Protein Name
Calpain-5
Scientific Description
Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3. [provided by RefSeq]
Reactivity
Human, Mouse, Rat
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Geddes JW, Bondada V, Croall DE, et al. Impaired activity and membrane association of most calpain-5 mutants causal for neovascular inflammatory vitreoretinopathy. Biochim Biophys Acta Mol Basis Dis. 2023,1869(6):166747. doi: 10.1016/j.bbadis.2023.166747
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Bondada V, Gal J, Mashburn C, et al. The C2 domain of calpain 5 contributes to enzyme activation and membrane localization. Biochim Biophys Acta Mol Cell Res. 2021,1868(7):119019. doi: 10.1016/j.bbamcr.2021.119019
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Chukai Y, Iwamoto T, Itoh K, et al. Characterization of mitochondrial calpain-5. Biochim Biophys Acta Mol Cell Res. 2021,1868(5):118989. doi: 10.1016/j.bbamcr.2021.118989
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Velez G, Bassuk AG, Schaefer KA, et al. A novel de novo CAPN5 mutation in a patient with inflammatory vitreoretinopathy, hearing loss, and developmental delay. Cold Spring Harb Mol Case Stud. 2018,4(3). doi: 10.1101/mcs.a002519
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Schaefer KA, Toral MA, Velez G, et al. Calpain-5 Expression in the Retina Localizes to Photoreceptor Synapses. Invest Ophthalmol Vis Sci. 2016,57(6):2509-21. doi: 10.1167/iovs.15-18680
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