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ProductsBack/Calpain 5 antibody [N1C1]

Calpain 5 antibody [N1C1]

GTX103264
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetCAPN5
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Overview

  • Supplier
    GeneTex
  • Product Name
    Calpain 5 antibody [N1C1]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.39 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID726
  • Target name
    CAPN5
  • Target description
    calpain 5
  • Target synonyms
    ADNIV; calpain htra-3; calpain-5; HTRA3; nCL-3; new calpain 3; testis tissue sperm-binding protein Li 91mP; VRNI
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDO15484
  • Protein Name
    Calpain-5
  • Scientific Description
    Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Impaired activity and membrane association of most calpain-5 mutants causal for neovascular inflammatory vitreoretinopathy.
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  • The C2 domain of calpain 5 contributes to enzyme activation and membrane localization. Bondada V et al., 2021 Jun, Biochim Biophys Acta Mol Cell Res
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  • Characterization of mitochondrial calpain-5. Chukai Y et al., 2021 Apr, Biochim Biophys Acta Mol Cell Res
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  • A novel de novo CAPN5 mutation in a patient with inflammatory vitreoretinopathy, hearing loss, and developmental delay. Velez G et al., 2018 Jun, Cold Spring Harb Mol Case Stud
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  • Calpain-5 Expression in the Retina Localizes to Photoreceptor Synapses. Schaefer KA et al., 2016 May 1, Invest Ophthalmol Vis Sci
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