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CaMKII delta antibody

GTX111401
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetCAMK2D
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Overview

  • Supplier
    GeneTex
  • Product Name
    CaMKII delta antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:50000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.66 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID817
  • Target name
    CAMK2D
  • Target description
    calcium/calmodulin dependent protein kinase II delta
  • Target synonyms
    CAMKD, calcium/calmodulin-dependent protein kinase type II subunit delta, CaM kinase II delta subunit, CaM-kinase II delta chain, CaMK-II delta subunit, calcium/calmodulin-dependent protein kinase (CaM kinase) II delta, calcium/calmodulin-dependent protein kinase type II delta chain
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ13557
  • Protein Name
    Calcium/calmodulin-dependent protein kinase type II subunit delta
  • Scientific Description
    The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Shiba N, Yang X, Sato M, et al. Efficacy of exon-skipping therapy for DMD cardiomyopathy with mutations in actin binding domain 1. Mol Ther Nucleic Acids. 2023,34:102060. doi: 10.1016/j.omtn.2023.102060
    Read this paper
  • Lee TI, Trang NN, Lee TW, et al. Ketogenic Diet Regulates Cardiac Remodeling and Calcium Homeostasis in Diabetic Rat Cardiomyopathy. Int J Mol Sci. 2023,24(22). doi: 10.3390/ijms242216142
    Read this paper
  • Rocco-Machado N, Lai L, Kim G, et al. Oxidative stress-induced autonomous activation of the calcium/calmodulin-dependent kinase II involves disulfide formation in the regulatory domain. J Biol Chem. 2022,298(11):102579. doi: 10.1016/j.jbc.2022.102579
    Read this paper
  • Zhang M, Zhang J, Zhang W, et al. CaMKII-δ9 Induces Cardiomyocyte Death to Promote Cardiomyopathy and Heart Failure. Front Cardiovasc Med. 2021,8:820416. doi: 10.3389/fcvm.2021.820416
    Read this paper
  • Lee TW, Chung CC, Lee TI, et al. Fibroblast Growth Factor 23 Stimulates Cardiac Fibroblast Activity through Phospholipase C-Mediated Calcium Signaling. Int J Mol Sci. 2021,23(1). doi: 10.3390/ijms23010166
    Read this paper
  • Zhong G, Zhao D, Li J, et al. WWP1 Deficiency Alleviates Cardiac Remodeling Induced by Simulated Microgravity. Front Cell Dev Biol. 2021,9:739944. doi: 10.3389/fcell.2021.739944
    Read this paper
  • Joseph LC, Reyes MV, Homan EA, et al. The mitochondrial calcium uniporter promotes arrhythmias caused by high-fat diet. Sci Rep. 2021,11(1):17808. doi: 10.1038/s41598-021-97449-3
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  • Hung Y, Chen YC, Huang SY, et al. Klotho modulates electrical activity and calcium homeostasis in pulmonary vein cardiomyocytes via PI3K/Akt signalling. Europace. 2020,22(7):1132-1141. doi: 10.1093/europace/euaa100
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  • Liu C, Zhong G, Zhou Y, et al. Alteration of calcium signalling in cardiomyocyte induced by simulated microgravity and hypergravity. Cell Prolif. 2020,53(3):e12783. doi: 10.1111/cpr.12783
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  • Himelman E, Lillo MA, Nouet J, et al. Prevention of connexin-43 remodeling protects against Duchenne muscular dystrophy cardiomyopathy. J Clin Invest. 2020,130(4):1713-1727. doi: 10.1172/JCI128190
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