CAND1 antibody

GeneTex

CAND1 Antibody

9

WB: 1:500-1:1000. ELISA: 1:2000-1:10000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

CAND1

cullin associated and neddylation dissociated 1

cullin-associated NEDD8-dissociated protein 1; p120 CAND1; TBP-interacting protein of 120 kDa A; TIP120; TIP120A

Rabbit

IgG

Cullin-associated NEDD8-dissociated protein 1

CAND1 is also known as TIP120A, and TATA-binding protein-interacting protein 120A. The SCF complex consists of the invariable components Skp1, Cul1, and Rbx1 as well as a variable F-box protein, and functions as an E3 ubiquitin ligase. E3 ubiquitin ligases regulate various physiological processes. CAND1 binds to Cul1 and potentially regulates the SCF complex. CAND1 physically associates with Cul1 in the nucleus and this interaction is mediated by a central region of Cul1 distinct from its binding sites for Skp1 and Rbx1. CAND1 selectively binds to unneddylated CUL1 and is dissociated by CUL1 neddylation. CAND1 forms a ternary complex with CUL1 and ROC1.

Human

-20°C or -80°C,2°C to 8°C

12352203