CARD8 antibody

GeneTex

CARD8 antibody

9

WB: 1:500 - 1:2000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot

Research Use Only

Polyclonal

Unconjugated

CARD8

caspase recruitment domain family member 8

apoptotic protein NDPP1; CARD inhibitor of NF-kappaB-activating ligands; CARDINAL; caspase recruitment domain-containing protein 8; DACAR; DAKAR; NDPP; NDPP1; TUCAN; tumor up-regulated CARD-containing antagonist of CASP9; tumor up-regulated CARD-containing antagonist of caspase nine

Rabbit

IgG

Caspase recruitment domain-containing protein 8

The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]

Human

-20°C or -80°C,2°C to 8°C

12352203