Caspase 9 (cleaved Asp330) antibody
GTX132331
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman, Rat
TargetCASP9
Overview
- SupplierGeneTex
- Product NameCaspase 9 (cleaved Asp330) antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration2.73 mg/ml
- ConjugateUnconjugated
- Gene ID842
- Target nameCASP9
- Target descriptioncaspase 9
- Target synonymsAPAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56, caspase-9, ICE-like apoptotic protease 6, apoptotic protease MCH-6, apoptotic protease activating factor 3, caspase 9, apoptosis-related cysteine peptidase, protein phosphatase 1, regulatory subunit 56
- HostRabbit
- IsotypeIgG
- Protein IDP55211
- Protein NameCaspase-9
- Scientific DescriptionThis gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
- ReactivityHuman, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
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- Xing R, Liu X, Tian B, et al. Neuroprotective effect of Na(+) /H(+) exchangers isoform-1 inactivation against 6-hydroxydopamine-induced mitochondrial dysfunction and neuronal apoptosis in Parkinson's disease models. Drug Dev Res. 2021,82(7):969-979. doi: 10.1002/ddr.21799Read this paper
- Yan D, Wei H, Lai X, et al. Co-delivery of homoharringtonine and doxorubicin boosts therapeutic efficacy of refractory acute myeloid leukemia. J Control Release. 2020,327:766-778. doi: 10.1016/j.jconrel.2020.09.031Read this paper
- Wang YY, Xiao LY, Chen YK, et al. Orabase-Formulated Benzalkonium Chloride Effectively Suppressed Oral Potentially Malignant Disorder In Vitro and In Vivo. ACS Omega. 2020,5(12):7018-7024. doi: 10.1021/acsomega.0c00640Read this paper
- Cui Z, Bao X, Liu Q, et al. MicroRNA-378-3p/5p represses proliferation and induces apoptosis of oral squamous carcinoma cells via targeting KLK4. Clin Exp Pharmacol Physiol. 2020,47(4):713-724. doi: 10.1111/1440-1681.13235Read this paper
- Tedeschi V, Petrozziello T, Sisalli MJ, et al. The activation of Mucolipin TRP channel 1 (TRPML1) protects motor neurons from L-BMAA neurotoxicity by promoting autophagic clearance. Sci Rep. 2019,9(1):10743. doi: 10.1038/s41598-019-46708-5Read this paper
- Dasgupta A, Dey D, Ghosh D, et al. Astrakurkurone, a sesquiterpenoid from wild edible mushroom, targets liver cancer cells by modulating Bcl-2 family proteins. IUBMB Life. 2019,71(7):992-1002. doi: 10.1002/iub.2047Read this paper
- Chen CC, Chen CY, Wang SH, et al. Melatonin Sensitizes Hepatocellular Carcinoma Cells to Chemotherapy Through Long Non-Coding RNA RAD51-AS1-Mediated Suppression of DNA Repair. Cancers (Basel). 2018,10(9). doi: 10.3390/cancers10090320Read this paper
- Chen CC, Chen CY, Ueng SH, et al. Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair. Cell Death Dis. 2018,9(5):543. doi: 10.1038/s41419-018-0575-0Read this paper






![WB analysis of active 293 (lane 2) and inactive 293 cell lysate(lane 1) using GTX30245 Caspase 9 antibody [LAP6 96-2-22].](https://www.genetex.com/upload/website/prouct_img/normal/GTX30245/GTX30245_1377_WB_w_23060722_265.webp)