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Caspase 9 (cleaved Asp330) antibody

GTX132331
GeneTex
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman, Rat
TargetCASP9
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Overview

  • Supplier
    GeneTex
  • Product Name
    Caspase 9 (cleaved Asp330) antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    2.73 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID842
  • Target name
    CASP9
  • Target description
    caspase 9
  • Target synonyms
    APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56, caspase-9, ICE-like apoptotic protease 6, apoptotic protease MCH-6, apoptotic protease activating factor 3, caspase 9, apoptosis-related cysteine peptidase, protein phosphatase 1, regulatory subunit 56
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP55211
  • Protein Name
    Caspase-9
  • Scientific Description
    This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
  • Reactivity
    Human, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

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  • Xing R, Liu X, Tian B, et al. Neuroprotective effect of Na(+) /H(+) exchangers isoform-1 inactivation against 6-hydroxydopamine-induced mitochondrial dysfunction and neuronal apoptosis in Parkinson's disease models. Drug Dev Res. 2021,82(7):969-979. doi: 10.1002/ddr.21799
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  • Yan D, Wei H, Lai X, et al. Co-delivery of homoharringtonine and doxorubicin boosts therapeutic efficacy of refractory acute myeloid leukemia. J Control Release. 2020,327:766-778. doi: 10.1016/j.jconrel.2020.09.031
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  • Wang YY, Xiao LY, Chen YK, et al. Orabase-Formulated Benzalkonium Chloride Effectively Suppressed Oral Potentially Malignant Disorder In Vitro and In Vivo. ACS Omega. 2020,5(12):7018-7024. doi: 10.1021/acsomega.0c00640
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  • Cui Z, Bao X, Liu Q, et al. MicroRNA-378-3p/5p represses proliferation and induces apoptosis of oral squamous carcinoma cells via targeting KLK4. Clin Exp Pharmacol Physiol. 2020,47(4):713-724. doi: 10.1111/1440-1681.13235
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  • Tedeschi V, Petrozziello T, Sisalli MJ, et al. The activation of Mucolipin TRP channel 1 (TRPML1) protects motor neurons from L-BMAA neurotoxicity by promoting autophagic clearance. Sci Rep. 2019,9(1):10743. doi: 10.1038/s41598-019-46708-5
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  • Dasgupta A, Dey D, Ghosh D, et al. Astrakurkurone, a sesquiterpenoid from wild edible mushroom, targets liver cancer cells by modulating Bcl-2 family proteins. IUBMB Life. 2019,71(7):992-1002. doi: 10.1002/iub.2047
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  • Chen CC, Chen CY, Wang SH, et al. Melatonin Sensitizes Hepatocellular Carcinoma Cells to Chemotherapy Through Long Non-Coding RNA RAD51-AS1-Mediated Suppression of DNA Repair. Cancers (Basel). 2018,10(9). doi: 10.3390/cancers10090320
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  • Chen CC, Chen CY, Ueng SH, et al. Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair. Cell Death Dis. 2018,9(5):543. doi: 10.1038/s41419-018-0575-0
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