CBFA2T3 Antibody

Cusabio

CBFA2T3 Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

CBFA2T3

CBFA2/RUNX1 partner transcriptional co-repressor 3

ETO2, MTG16, MTGR2, RUNX1T3, ZMYND4, protein CBFA2T3, CBFA2/RUNX1 translocation partner 3, MTG8-related gene 2, MTG8-related protein 2, core-binding factor, runt domain, alpha subunit 2; translocated to, 3, myeloid translocation gene 8 and 16b, myeloid translocation gene on chromosome 16 protein, zinc finger MYND domain-containing protein 4

Rabbit

IgG

Protein CBFA2T3

Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Plays a role in granulocyte differentiation (PubMed:15231665).

Human

-20°C or -80°C

41116161