CBR-5884 [681159-27-3]

MedChem Express

CBR-5884 [681159-27-3]

5

681159-27-3

Research Use Only

98.74%

C14H12N2O4S2

336.39

CBR-5884 is an active, selective inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC50 of 33 microM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis.

O=C(C1=C(C)C(SC#N)=C(NC(C2=CC=CO2)=O)S1)OCC

2°C to 8°C,-20°C,-80°C

12352200