![CBR-5884 [681159-27-3] CBR-5884 [681159-27-3]](https://www.targetmol.com/group3/M00/36/05/CgoaEGayNEiEViryAAAAAOM9KqA583.png)
CBR-5884 [681159-27-3]
T14884
Overview
- SupplierTargetMol Chemicals
- Product NameCBR-5884 [681159-27-3]
- Delivery Days Customer4
- CAS Number681159-27-3
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical NameCBR-5884
- Molecular FormulaC14H12N2O4S2
- Molecular Weight336.39
- Scientific DescriptionCBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 microM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis. Biochemical characterization of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDH
- Shelf life instruction3 years
- SMILESCCOC(=O)c1sc(NC(=O)c2ccco2)c(SC#N)c1C
- Storage Instruction-20°C
- UNSPSC12352200