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CBR-5884 [681159-27-3]

CBR-5884 [681159-27-3]

T14884
TargetMol Chemicals
CAS Number681159-27-3
Product group Chemicals
Molecular Weight336.39
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    CBR-5884 [681159-27-3]
  • Delivery Days Customer
    4
  • CAS Number
    681159-27-3
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    CBR-5884
  • Molecular Formula
    C14H12N2O4S2
  • Molecular Weight
    336.39
  • Scientific Description
    CBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 microM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis. Biochemical characterization of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDH
  • Shelf life instruction
    3 years
  • SMILES
    CCOC(=O)c1sc(NC(=O)c2ccco2)c(SC#N)c1C
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

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