CC-90005

Biorbyt

CC-90005

10

1799574-70-1

Research Use Only

C21H27F2N7O2

447.4816

CC-90005 is a potent, selective and orally active inhibitor of protein kinase C-theta (PKC-theta), with an IC50 of 8 nM. CC-90005 shows selectivity for PKC-theta over PKC-delta (IC50=4440 nM). CC-90005 can inhibit T cell activation by IL-2 expression.

FC(C([H])([H])[H])(C([H])([H])OC1C(=C([H])N=C([H])N=1)C([H])([H])N([H])C1=NC([H])=C(C#N)C(=N1)N([H])[C@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])O[H])F

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