Western blot analysis of extracts from Jurkat cells, using KIAA1967 antibody.
Western blot analysis of extracts from Jurkat cells, using KIAA1967 antibody.
CCAR2 Antibody
CSB-PA084028
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetCCAR2
Overview
- SupplierCusabio
- Product NameCCAR2 Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID57805
- Target nameCCAR2
- Target descriptioncell cycle and apoptosis regulator 2
- Target synonymscell cycle and apoptosis regulator protein 2; cell division cycle and apoptosis regulator protein 2; DBC1; DBC-1; deleted in breast cancer 1; KIAA1967; NET35; p30 DBC; p30DBC
- HostRabbit
- IsotypeIgG
- Protein IDQ8N163
- Protein NameCell cycle and apoptosis regulator protein 2
- Scientific DescriptionCore component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Nagase T., DNA Res. 8:319-327(2001). Hamaguchi M., Proc. Natl. Acad. Sci. U.S.A. 99:13647-13652(2002). Olsen J.V., Cell 127:635-648(2006).
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203