CCM2 antibody

GeneTex

CCM2 antibody

9

WB: 1:500 - 1:2000. IHC-P: 1:50 - 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

Unconjugated

CCM2

CCM2 scaffold protein

C7orf22; CCM2 scaffolding protein; cerebral cavernous malformation 2; cerebral cavernous malformations 2 protein; malcavernin; OSM; osmosensing scaffold for MEKK3; PP10187

Rabbit

IgG

Cerebral cavernous malformations 2 protein

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]

-20°C or -80°C,2°C to 8°C

12352203