WB analysis of human heart lysate using GTX89245 CCM2 antibody, Internal. Dilution : 0.03microg/ml Loading : 35microg protein in RIPA buffer
WB analysis of human heart lysate using GTX89245 CCM2 antibody, Internal. Dilution : 0.03microg/ml Loading : 35microg protein in RIPA buffer
CCM2 antibody, Internal
GTX89245
Overview
- SupplierGeneTex
- Product NameCCM2 antibody, Internal
- Delivery Days Customer9
- Antibody SpecificityThis antibody is expected to recognize isoform 1 (NP_001025006.1), isoform 2 (NP_113631.1) and isoform 4 (NP_001161407.1).
- Application Supplier NoteWB: 0.03-0.1microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.50 mg/ml
- ConjugateUnconjugated
- FormulationLiquid
- Gene ID83605
- Target nameCCM2
- Target descriptionCCM2 scaffold protein
- Target synonymsC7orf22; CCM2 scaffolding protein; cerebral cavernous malformation 2; cerebral cavernous malformations 2 protein; malcavernin; OSM; osmosensing scaffold for MEKK3; PP10187
- HostGoat
- IsotypeIgG
- Protein IDQ9BSQ5
- Protein NameCerebral cavernous malformations 2 protein
- Scientific DescriptionThis gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]
- ReactivityHuman
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203