Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA004814ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA004814ESR2HU at dilution of 1:100
CCND3 Antibody
CSB-PA004814ESR2HU
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetCCND3
Overview
- SupplierCusabio
- Product NameCCND3 Antibody
- Delivery Days Customer20
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID896
- Target nameCCND3
- Target descriptioncyclin D3
- Target synonymsD3-type cyclin; G1/S-specific cyclin-D3
- HostRabbit
- IsotypeIgG
- Protein IDP30281
- Protein NameG1/S-specific cyclin-D3
- Scientific DescriptionRegulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203