CD130 antibody
GTX109048
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetIL6ST
Overview
- SupplierGeneTex
- Product NameCD130 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.1 mg/ml
- ConjugateUnconjugated
- Gene ID3572
- Target nameIL6ST
- Target descriptioninterleukin 6 cytokine family signal transducer
- Target synonymsCD130, CDW130, GP130, HIES4, HIES4A, HIES4B, IL-6RB, IMD94, STWS2, sGP130, interleukin-6 receptor subunit beta, CD130 antigen, IL-6 receptor subunit beta, IL-6R subunit beta, gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form, gp130, oncostatin M receptor, interleukin receptor beta chain, interleukin-6 signal transducer, membrane glycoprotein 130, membrane glycoprotein gp130, oncostatin-M receptor subunit alpha
- HostRabbit
- IsotypeIgG
- Protein IDP40189
- Protein NameInterleukin-6 receptor subunit beta
- Scientific DescriptionThe protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Ma B, Yang L, Jing R, et al. Effects of Interleukin-6 on posterior capsular opacification. Exp Eye Res. 2018,172:94-103. doi: 10.1016/j.exer.2018.03.013Read this paper
- Pathare ADS, Zaveri K, Hinduja I. Downregulation of genes related to immune and inflammatory response in IVF implantation failure cases under controlled ovarian stimulation. Am J Reprod Immunol. 2017,78(1). doi: 10.1111/aji.12679Read this paper
- Zhang Y, Ma Q, Liu T, et al. Tumor self-seeding by circulating tumor cells in nude mouse models of human osteosarcoma and a preliminary study of its mechanisms. J Cancer Res Clin Oncol. 2014,140(2):329-40. doi: 10.1007/s00432-013-1561-7Read this paper




