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ProductsBack/CD146 antibody [C1C3]

CD146 antibody [C1C3]

Research Use Only
GTX108777
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetMCAM
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Overview

  • Supplier
    GeneTex
  • Product Name
    CD146 antibody [C1C3]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.21 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID4162
  • Target name
    MCAM
  • Target description
    melanoma cell adhesion molecule
  • Target synonyms
    CD146; cell surface glycoprotein MUC18; cell surface glycoprotein P1H12; Gicerin; HEMCAM; melanoma adhesion molecule; melanoma-associated antigen A32; melanoma-associated antigen MUC18; MelCAM; METCAM; MUC18; S-endo 1 endothelial-associated antigen
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP43121
  • Protein Name
    Cell surface glycoprotein MUC18
  • Scientific Description
    Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Neuronal and Endothelial Transglutaminase-2 Expression during Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis. Pearse DD et al., 2021 May 1, Neuroscience
    Read more
  • Defactinib attenuates osteoarthritis by inhibiting positive feedback loop between H-type vessels and MSCs in subchondral bone. Hu Y et al., 2020 Sep, J Orthop Translat
    Read more
  • Exosomal 2,3-CNP from mesenchymal stem cells promotes hippocampus CA1 neurogenesis/neuritogenesis and contributes to rescue of cognition/learning deficiencies of damaged brain. Chen SY et al., 2020 Apr, Stem Cells Transl Med
    Read more
  • Cryoprotectant-free cryopreservation of mammalian cells by superflash freezing. Akiyama Y et al., 2019 Apr 16, Proc Natl Acad Sci U S A
    Read more