IHC-Fr staining of a human tonsil with Mouse anti Human CD163 antibody, clone EDHu-1 (GTX42364), red in A and Mouse anti Human CD21 antibody, clone LB21 (GTX74728), green in B. C is the merged image with nuclei counterstained blue using DAPI. High power
![IHC-Fr analysis of human tonsil tissue using GTX42364 CD163 antibody [EDHu-1].](https://www.genetex.com/upload/website/prouct_img/normal/GTX42364/GTX42364_817_IHC-Fr_w_23060820_901.webp "IHC-Fr analysis of human tonsil tissue using GTX42364 CD163 antibody [EDHu-1].")
![IHC-Fr analysis of human tonsil tissue using GTX42364 CD163 antibody [EDHu-1].](https://www.genetex.com/upload/website/prouct_img/normal/GTX42364/GTX42364_818_IHC-Fr_w_23060820_380.webp "IHC-Fr analysis of human tonsil tissue using GTX42364 CD163 antibody [EDHu-1].")
![IHC-Fr analysis of human tonsil tissue using GTX42364 CD163 antibody [EDHu-1].](https://www.genetex.com/upload/website/prouct_img/normal/GTX42364/GTX42364_819_IHC-Fr_w_23060820_538.webp "IHC-Fr analysis of human tonsil tissue using GTX42364 CD163 antibody [EDHu-1].")
IHC-Fr staining of a human tonsil with Mouse anti Human CD163 antibody, clone EDHu-1 (GTX42364), red in A and Mouse anti Human CD21 antibody, clone LB21 (GTX74728), green in B. C is the merged image with nuclei counterstained blue using DAPI. High power
CD163 antibody [EDHu-1]
GTX42364
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin, Other Application
Product group Antibodies
ReactivityBovine, Guinea Pig, Human, Porcine, Primate, Sheep
TargetCD163
Overview
- SupplierGeneTex
- Product NameCD163 antibody [EDHu-1]
- Delivery Days Customer9
- Antibody SpecificityThe Binding of EDHu-1 occurs via the N-terminal region of CD163 containing the first three scavenger receptor, Cysteine-rich, SRCR domains the third domain being critical as, cleavage of this domain at the major cleavage site ASP-265 abrogates binding to
- ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin, Other Application
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDEDHu-1
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID9332
- Target nameCD163
- Target descriptionCD163 molecule
- Target synonymshemoglobin scavenger receptor; M130; macrophage-associated antigen; MM130; SCARI1; scavenger receptor cysteine-rich type 1 protein M130
- HostMouse
- IsotypeIgG1
- Scientific DescriptionThe protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
- ReactivityBovine, Guinea Pig, Human, Porcine, Primate, Sheep
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203
References
- Antipruritic effects of electroacupuncture on morphine-induced pruritus model mice through the TLR2/4-MyD88-NF-kappaB pathway. Ye YS et al., 2019 Mar 20, NeuroreportRead more
- High expression of B7-H3 and CD163 in cancer tissues indicates malignant clinicopathological status and poor prognosis of patients with urothelial cell carcinoma of the bladder. Xu Z et al., 2018 May, Oncol LettRead more
- The c.1085A>G Genetic Variant of CSF1R Gene Regulates Tumor Immunity by Altering the Proliferation, Polarization, and Function of Macrophages. Yeh YM et al., 2017 Oct 15, Clin Cancer ResRead more