Immunofluorescence staining of Hela cells with CSB-PA801238LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CD163 Antibody

CSB-PA801238LA01HU

ApplicationsImmunoFluorescence, ELISA

Product group Antibodies

TargetCD163

Overview

Supplier
Cusabio
Product Name
CD163 Antibody
Delivery Days Customer
20
Applications
ImmunoFluorescence, ELISA
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID9332
Target name
CD163
Target description
CD163 molecule
Target synonyms
hemoglobin scavenger receptor; M130; macrophage-associated antigen; MM130; SCARI1; scavenger receptor cysteine-rich type 1 protein M130
Host
Rabbit
Isotype
IgG
Protein IDQ86VB7
Protein Name
Scavenger receptor cysteine-rich type 1 protein M130
Scientific Description
Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.
Storage Instruction
-20°C or -80°C
UNSPSC
12352203

CD163 Antibody

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Overview

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