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CD177 antibody [MEM-166] (APC)

Name: CD177 antibody [MEM-166] (APC)
SKU: GTX79995_G10
Availability: BackOrder

GTX79995

TargetCD177

Product group Antibodies

Overview

Supplier
GeneTex
Product Name
CD177 antibody [MEM-166] (APC)
Delivery Days Customer
9
Application Supplier Note
FACS: 10 microl reagent / 100 microl of whole blood or 106 cells in a suspension. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Clone ID
MEM-166
Formulation
Liquid
Gene ID57126
Target name
CD177
Target description
CD177 molecule
Target synonyms
CD177 antigen; cell surface receptor; HNA2A; HNA-2a; human neutrophil alloantigen 2a; NB1; NB1 glycoprotein; NB1 GP; polycythemia rubra vera protein 1; PRV1; PRV-1
Protein IDQ8N6Q3
Protein Name
CD177 antigen
Scientific Description
This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegeners granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014]
Storage Instruction
2°C to 8°C
UNSPSC
12352203

Loss of expression of neutrophil proteinase-3: a factor contributing to thrombotic risk in paroxysmal nocturnal hemoglobinuria. Jankowska AM et al., 2011 Jul, Haematologica
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